答根据片段，不显著相关。关键证据：一项单中心回顾性研究纳入 825 例中重度及重度急性胰腺炎（AP）患者，其中 541 例住院期间接受华法林或低分子肝素（LMWH）早期预防性抗凝，结果显示「early prophylactic anticoagulation was not significantly associated with the occurrence of PPH」，即早期预防性抗凝与胰源性门静脉高压（PPH）的发生无显著相关。P9
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Summary of critical evidence: Portal and splenic vein thrombosis are common complications of AP, which may lead to regional portal hypertension [80]. In a single-center retrospective study including 825 patients with moderately severe and severe AP, of whom 541 received warfarin or low-molecular-weight heparin (LMWH) during hospitalization, early prophylactic anticoagulation was not significantly associated with the occurrence of PPH [47]. Therefore, current evidence does not support routine anticoagulation to prevent PPH in AP. Another retrospective study reported that early systemic anticoagulation significantly reduced the incidence of splanchnic vein thrombosis in patients with acute necrotizing pancreatitis, and was associated with lower rates of organ failure and in-hospital mortality without increased risk of bleeding complications [81]. Thus, anticoagulation may be considered to prevent splanchnic thrombosis in acute necrotizing pancreatitis, but its benefits on the prophylaxis of PPH remain unclear
